Condition focus · Depression
Major depressive disorder, persistent depressive disorder
~21M US adults annually · ~8% point prevalence (NIMH)
Frontal alpha asymmetry protocols target the left-right prefrontal asymmetry seen in depression. EEGBase supports both EEG-based and Mendi fNIRS-based approaches with concurrent PHQ-9 tracking.
Protocols
Alpha asymmetry (FAA) up-train left
Channel: F3 / F4
Frequency: Reward L-alpha relative to R-alpha
Sessions: 20–30
Mendi prefrontal up-train
Channel: Fp1 / Fp2
Frequency: Beer-Lambert HbO
Sessions: 20
Theta down-train (anhedonia variant)
Channel: Fz
Frequency: 4–8 Hz inhibit
Sessions: 20–30
Effect sizes reported in the published literature (illustrative)
PHQ-9
−7 pts (lit.)
Reported in FAA NF trials (Choi 2011)
BDI-II
−7 pts
Reported in published depression NF subsets
Frontal alpha asymmetry
+0.32 SD
L > R shift across sessions · literature
Evidence base
- Choi et al. (2011) — RCT of frontal alpha asymmetry NF for depression
- Hammond (2005) — neurofeedback for affective disorders review
- Trambaiolli et al. (2021) — fNIRS NF for depression (working-memory adjunct)
Try the Depression demo
Pre-loaded session for a major depressive disorder client. No sign-up.
Open the demo →EEGBase is a software platform, not a medical device, and does not diagnose, treat, cure, or prevent any disease. Effect sizes shown are illustrative figures drawn from the published academic literature, not from an EEGBase outcomes registry. EEGBase has not yet completed any clinical study of its own. Always confirm protocols with a credentialed clinician.