Condition focus · Depression

Major depressive disorder, persistent depressive disorder

~21M US adults annually · ~8% point prevalence (NIMH)

Frontal alpha asymmetry protocols target the left-right prefrontal asymmetry seen in depression. EEGBase supports both EEG-based and Mendi fNIRS-based approaches with concurrent PHQ-9 tracking.

Protocols

Alpha asymmetry (FAA) up-train left

Channel: F3 / F4

Frequency: Reward L-alpha relative to R-alpha

Sessions: 20–30

Mendi prefrontal up-train

Channel: Fp1 / Fp2

Frequency: Beer-Lambert HbO

Sessions: 20

Theta down-train (anhedonia variant)

Channel: Fz

Frequency: 4–8 Hz inhibit

Sessions: 20–30

Typical outcomes (illustrative, registry-derived)

PHQ-9

−6.8 pts mean

Multi-clinic registry · n=412

BDI-II

−7.4 pts

Subset with formal BDI-II tracking

Frontal alpha asymmetry

+0.32 SD

L > R shift across sessions

Evidence base

Choi et al. (2011) — RCT of frontal alpha asymmetry NF for depression
Hammond (2005) — neurofeedback for affective disorders review
Trambaiolli et al. (2021) — fNIRS NF for depression (working-memory adjunct)

Try the Depression demo

Pre-loaded session for a major depressive disorder client. No sign-up.

Open the demo →

EEGBase is a software platform, not a medical device. Outcome figures are illustrative registry-derived medians. Always confirm protocols with a credentialed clinician.